Axway Controlled Substance Ordering System (CSOS)
A modern API-enabled approach to achieving DEA regulatory compliance while ensuring security and reducing costs
Axway CSOS benefits
Reach your current and future objectives for DEA compliance and business with Axway Controlled Substance Ordering System software
SaaS open API strategy
Gain business agility and speed to meet today's demands – and tomorrow's – by leveraging an open API approach to CSOS that works across your digital ecosystem
Efficiency and scalability
Process large volumes of orders more effectively with a scalable CSOS solution whether you're a controlled substance manufacturer, distributor, dispenser, or pharmacy
Simple registration and certification management
Increase user engagement and satisfaction with a consistent user experience and simple integration. Axway CSOS manages certificates out of the box for compatibility with modern applications
Cutting-edge security
Axway worked directly with the Drug Enforcement Agency to build a secure, Drummond-Certified CSOS solution that requires no redirects or complex authentication schemes
The pillars of Axway CSOS
Digital Form 222 creation
Take the manual effort out of controlled substance ordering by processing electronic 222 controlled substance orders in real-time with full DEA compliance. DEA Form 222a and DEA Form 224 are related CSOS forms.
Secure certificate vault
As users register on the system, certificates are uploaded to the secure vault through an integrated customer portal that gives users a familiar interface with seamless interaction.
Certificate and password Verification
Certificates are cross-referenced against the control revocation list published by the DEA. This prevents any inactive certificates from being used in the signing process. Valid certificates are signed using a password known only to the certificate owner.
Next-gen CSOS user interface
The modern web-based user interface makes life easier with simplified navigation and enhanced user experience for onboarding and managing users, order filtering, locking orders, and more.
Axway CSOS capabilities
Secure, multi-use, multi-deployment CSOS solution capabilities along the entire supply chain
End-to-end reliability
Axway CSOS provides DEA Form 222 processing, license verification, certificate revocation and management, and other capabilities for manufacturers, distributors, dispensers, and pharmacies.
Multi-role deployment
Distribution customers are responsible for CSOS on the purchase side from manufacturers and as a signing resource for customers. Axway CSOS provides integration functionality across all roles.
CSOS central signing
Axway CSOS supports a central signing workflow for customers relying on a dispenser network with central signing authority.
Multi-use solution, inside and out
Axway CSOS technology offers robust back-end versatility that allows customers to successfully extend their use cases outside of direct, CSOS-related applications.
CSOS certificate upload utility
Speed and smoothly scale processes by uploading certificates in bulk and automating certificate importing and renewal.
CSOS order validation
Identify and fix data issues with the DEA by automatically identifying noncompliant CSOS orders, notifying users, and keeping bad orders from reaching the signing process.
Containerized architecture
Leverage the optional containerized deployment architecture on Axway B2Bi Enterprise Edition for high availability, zero downtime maintenance, deployment automation, and the confidence that systems will stay up and running.
Paperless enrollment
Take advantage of the DEA's enhanced online CSOS enrollment system by going fully paperless and streamlining your controlled substance ordering process.
Optimizing CSOS processes across 1500 locations
220,000 pharmaceutical orders processed a day
Frequently asked questions
Modern CSOS. What it is. Why it's important.
What is Axway CSOS?
Axway Controlled Substance Ordering System (CSOS) is a specialized solution that enables pharmaceutical companies, distributors, and pharmacies to securely manage electronic ordering of controlled substances in compliance with U.S. Drug Enforcement Administration (DEA) regulations.
It replaces paper-based processes (such as DEA Form 222) with fully digital, secure, and auditable transactions, improving efficiency and compliance.
When should I use Axway CSOS?
Axway CSOS is essential when organizations need to comply with DEA regulations for controlled substances, replace manual and paper-based ordering processes, and ensure secure, compliant transactions across the pharmaceutical supply chain.
It is particularly relevant for manufacturers, distributors, pharmacies, and logistics providers operating in regulated healthcare environments.
What makes Axway CSOS different from other CSOS solutions?
Axway CSOS stands out by combining DEA-compliant digital ordering with enterprise-grade scalability and integration, and is Drummond-certified, ensuring proven compliance with industry standards for secure electronic transactions.
It supports central signing workflows for organizations operating complex dispenser networks, enabling controlled and efficient order authorization at scale. Unlike standalone solutions, it integrates seamlessly with existing systems through API-driven architecture, while providing end-to-end visibility, auditability, and security across all transactions.
This allows organizations to go beyond basic compliance and build a scalable, automated, and future-ready controlled substance ordering process.
What capabilities does Axway CSOS provide?
Axway CSOS enables secure and compliant digital ordering of controlled substances by supporting electronic DEA Form 222 (e222) processing, along with digital signatures and certificate management.
It includes central signing workflows for organizations operating dispenser networks with a central signing authority, ensuring controlled and scalable order authorization. It also provides real-time transaction visibility, audit trails, and API-driven integration with enterprise systems.
This ensures full traceability, compliance, and operational efficiency across high-volume, regulated environments.
How does Axway CSOS ensure compliance and security?
Axway CSOS is designed to meet strict DEA regulatory requirements, with built-in controls for secure authentication, certificate validation, and long-term auditability.
It ensures end-to-end security through digital certificates and encryption, enforces compliance through automated validation of transactions, and maintains complete audit trails for inspections and reporting. As a Drummond-certified solution, it provides trusted, industry-recognized validation of secure electronic ordering.
This helps organizations reduce compliance risk, avoid penalties, and maintain secure, reliable supply chain operations.